As a network of independent locally governed organisations, the Alliance used its partnerships to inform the CAHR programme approach. The programmes in countries are being implemented by a consortium of Alliance Linking Organisations:

Technical expertise in programming and management and global advocacy support is being provided by a team of national and international partners: International HIV/AIDS Alliance in Ukraine, AIDS Foundation East West, Health Connections International, International Drug Policy Consortium, Harm Reduction InternationalInternational Network of People who Use Drugs and Prevention Information et Lutte contre le Sida.

This partnership allows ensuring expertise exchange, rapid start-up and innovation management; cost-effectiveness through project internal technical support 'market'; effective response to policy obstacles. On the country level the project became a source of vital international expertise that allowed contributing to overall response to HIV among people who use drugs.